BALANCING PRIVACY, PRECISION AND PERFORMANCE IN DISTRIBUTED SYSTEMS

Privacy, Precision, and Performance (3Ps) are three fundamental design objectives in distributed systems. However, these properties tend to compete with one another and are not considered absolute properties or functions. They must be defined and justified in terms of a system, its resources, stakeholder concerns, and the security threat model. To date, distributed systems research has only considered the trade-offs of balancing privacy, precision, and performance in a pairwise fashion. However, this dissertation formally explores the space of trade-offs among all 3Ps by examining three representative classes of distributed systems, namely Wireless Sensor Networks (WSNs), cloud systems, and Data Stream Management Systems (DSMSs). These representative systems support large part of the modern and mission-critical distributed systems. WSNs are real-time systems characterized by unreliable network interconnections and highly constrained computational and power resources. The dissertation proposes a privacy-preserving in-network aggregation protocol for WSNs demonstrating that the 3Ps could be navigated by adopting the appropriate algorithms and cryptographic techniques that are not prohibitively expensive. Next, the dissertation highlights the privacy and precision issues that arise in cloud databases due to the eventual consistency models of the cloud. To address these issues, consistency enforcement techniques across cloud servers are proposed and the trade-offs between 3Ps are discussed to help guide cloud database users on how to balance these properties. Lastly, the 3Ps properties are examined in DSMSs which are characterized by high volumes of unbounded input data streams and strict real-time processing constraints. Within this system, the 3Ps are balanced through a proposed simple and efficient technique that applies access control policies over shared operator networks to achieve privacy and precision without sacrificing the systems performance. Despite that in this dissertation, it was shown that, with the right set of protocols and algorithms, the desirable 3P properties can co-exist in a balanced way in well-established distributed systems, this dissertation is promoting the use of the new 3Ps-by-design concept. This concept is meant to encourage distributed systems designers to proactively consider the interplay among the 3Ps from the initial stages of the systems design lifecycle rather than identifying them as add-on properties to systems

Współczesne zagadnienia zarządzania: przedsiębiorstwo - biznes - region

Praca recenzowana / peer-reviewed pape

Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015 : findings from the Global Burden of Disease 2015 study

To report the burden of cardiovascular diseases (CVD) in the Eastern Mediterranean Region (EMR) during 1990-2015. We used the 2015 Global Burden of Disease study for estimates of mortality and disability-adjusted life years (DALYs) of different CVD in 22 countries of EMR. A total of 1.4 million CVD deaths (95% UI: 1.3-1.5) occurred in 2015 in the EMR, with the highest number of deaths in Pakistan (465,116) and the lowest number of deaths in Qatar (723). The age-standardized DALY rate per 100,000 decreased from 10,080 in 1990 to 8606 in 2015 (14.6% decrease). Afghanistan had the highest age-standardized DALY rate of CVD in both 1990 and 2015. Kuwait and Qatar had the lowest age-standardized DALY rates of CVD in 1990 and 2015, respectively. High blood pressure, high total cholesterol, and high body mass index were the leading risk factors for CVD. The age-standardized DALY rates in the EMR are considerably higher than the global average. These findings call for a comprehensive approach to prevent and control the burden of CVD in the region.Peer reviewe

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

ENERGY-GRID THREAT ANALYSIS USING HONEYPOTS

This research addresses cyber threats to smart energy grids. This research identified and characterized threats to electric-power grids by analysis of traffic in a simulated grid. We deployed a high-interaction honeypot that simulates a grid named GridPot. Network-traffic captures and honeypot-activity logs were analyzed to demonstrate the effectiveness of our honeypot at collecting intelligence for threat analysis. This study will contribute to the efforts of the Department of Defense and Department of Homeland Security to protect U.S. critical infrastructure from cyber threats.http://archive.org/details/energygridthreat1094562843Lieutenant, United States NavyLieutenant, United States NavyApproved for public release; distribution is unlimited

Chinese-German Relations and the Fourth Taiwan Strait Crisis

The purpose of this study was to understand the effect of the Fourth Taiwan Strait Crisis in 2022 and 2023 on Chinese–German relations. American–German relations were considered as the most important variable impacting relations between Beijing and Berlin. A methodological media content analysis, using context coding, was used to arrive at findings and discussion. An unstructured interview with an expert on media studies confirmed essentially the findings of the media content analysis. An integrated literature review on the American–German conflict indicated a contribution of the Crisis’s long-term effects to an essential, economic weakening of Germany in the years to come. Another Trump administration could deliver this outcome. Ultimately, the strategic partnership between China and Germany could end. German interaction with Beijing would politically be aligned with American interests. Control over Germany, Europe, the West, and world domination could be delivered to the United States. China and Russia would probably remain independent

Trichoderma harzianum-Mediated ZnO Nanoparticles: A Green Tool for Controlling Soil-Borne Pathogens in Cotton

ZnO-based nanomaterials have high antifungal effects, such as inhibition of growth and reproduction of some pathogenic fungi, such as Fusarium sp., Rhizoctonia solani and Macrophomina phaseolina. Therefore, we report the extracellular synthesis of ZnONPs using a potential fungal antagonist (Trichoderma harzianum). ZnONPs were then characterized for their size, shape, charge and composition by visual analysis, UV–visible spectrometry, X-ray diffraction (XRD), Zeta potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray analysis (EDX). The TEM test confirmed that the size of the produced ZnONPs was 8–23 nm. The green synthesized ZnONPs were characterized by Fourier transform infrared spectroscopy (FTIR) studies to reveal the functional group attributed to the formation of ZnONPs. For the first time, trichogenic ZnONPs were shown to have fungicidal action against three soil–cotton pathogenic fungi in the laboratory and greenhouse. An antifungal examination was used to evaluate the bioactivity of the mycogenic ZnONPs in addition to two chemical fungicides (Moncut and Maxim XL) against three soil-borne pathogens, including Fusarium sp., Rhizoctonia solani and Macrophomina phaseolina. The findings of this study show a novel fungicidal activity in in vitro assay for complete inhibition of fungal growth of tested plant pathogenic fungi, as well as a considerable reduction in cotton seedling disease symptoms under greenhouse conditions. The formulation of a trichogenic ZnONPs form was found to increase its antifungal effect significantly. Finally, the utilization of biocontrol agents, such as T. harzianum, could be a safe strategy for the synthesis of a medium-scale of ZnONPs and employ it for fungal disease control in cotton